abstract：:The increased lifespan caused by food limitation has been observed in a wide range of animals including the nematode Caenorhabditis elegans. We show here that the lifespans of eat-2 and eat-5 feeding-defective mutants and a mutant of dbl-1 encoding a TGFβ ligand significantly change between the cultures fed on Escheri...

journal_title：Mechanisms of ageing and development

authors： So S,Tokumaru T,Miyahara K,Ohshima Y

更新日期：2011-04-01 00:00:00

abstract：:To understand the effect of calorie restriction on genome maintenance systems, the age-dependent accumulation of mutations in animals maintained on high and low calorie diets was examined using lacZ-transgenic mice. Mice were fed a diet of 95 kcal/w or 65 kcal/w from 2 to 17 months of age. The mutation frequencies in ...

journal_title：Mechanisms of ageing and development

authors： He D,Uehara Y,Furuya M,Ikehata H,Komura J,Yamauchi K,Kakinuma S,Shang Y,Shimada Y,Ootsuyama A,Norimura T,Ono T

更新日期：2011-03-01 00:00:00

abstract：:Age-dependent renal damage is influenced by genetic background and the Fisher344xBrown Norway (F344xBN) rat is resistant to glomerular injury. In vulnerable strains, a fall in renal nitric oxide synthase (NOS) contributes to age-dependent renal damage. Here, we investigated renal NOS in young (3 months) and old (30 mo...

journal_title：Mechanisms of ageing and development

authors： Moningka NC,Sasser JM,Croker B,Carter C,Baylis C

更新日期：2011-01-01 00:00:00

abstract：:Hematological deficiencies increase with aging leading to anemias, reduced hematopoietic stress responses and myelodysplasias. This study tested the hypothesis that side population hematopoietic stem cells (SP-HSC) would decrease with aging, correlating with IGF-1 and IL-6 levels and increases in bone marrow fat. Marr...

journal_title：Mechanisms of ageing and development

authors： Brusnahan SK,McGuire TR,Jackson JD,Lane JT,Garvin KL,O'Kane BJ,Berger AM,Tuljapurkar SR,Kessinger MA,Sharp JG

更新日期：2010-11-01 00:00:00

abstract：:During adult life, the thymus involutes and thymic output of mature T cells drastically declines. The molecular events underlying this process are not well understood. Here, we present evidence of the importance of miRNAs in regulating T cell differentiation in the aged. miRNAs are a wide-ranging regulatory element in...

journal_title：Mechanisms of ageing and development

authors： Virts EL,Thoman ML

更新日期：2010-11-01 00:00:00

abstract：:In mammals, proliferation is rapid in many tissues during early postnatal life, causing rapid somatic growth. This robust proliferation is then suppressed as the animal approaches adult size, bringing many tissues to a quiescent state where proliferation occurs only as needed to replace dying cells. Recent evidence su...

journal_title：Mechanisms of ageing and development

authors： Lui JC,Chen W,Barnes KM,Baron J

更新日期：2010-10-01 00:00:00

abstract：:Recent studies show that cellular and mitochondrial iron increases with age. Iron overload, especially in mitochondria, increases the availability of redox-active iron, which may be a causal factor in the extensive age-related biomolecular oxidative damage observed in aged organisms. Such damage is thought to play a m...

journal_title：Mechanisms of ageing and development

authors： Xu J,Marzetti E,Seo AY,Kim JS,Prolla TA,Leeuwenburgh C

更新日期：2010-07-01 00:00:00

abstract：:Selenium (Se) is an essential trace mineral mediating its biological function primarily through selenoproteins. Accumulated lines of evidence indicate important roles of selenoproteins in the maintenance of optimal brain functions via redox regulation. Decreased expression of several selenoproteins is associated with ...

journal_title：Mechanisms of ageing and development

authors： Zhang S,Rocourt C,Cheng WH

更新日期：2010-04-01 00:00:00

abstract：:Skeletal muscle ageing is characterized by faulty degenerative/regenerative processes that promote the decline of its mass, strength, and endurance. In this study, we used a transcriptional profiling method to better understand the molecular pathways and factors that contribute to these processes. To more appropriatel...

journal_title：Mechanisms of ageing and development

authors： Scimè A,Desrosiers J,Trensz F,Palidwor GA,Caron AZ,Andrade-Navarro MA,Grenier G

更新日期：2010-01-01 00:00:00

abstract：:Elevated reactive oxygen species (ROS) levels have been observed in mammals during aging, implying an important role of ROS in the aging process. Most bird species are known to live longer and to contain lower ROS levels than mammals of the same body weight. The influence of ROS on the aging process of birds has been ...

journal_title：Mechanisms of ageing and development

authors： Strecker V,Mai S,Muster B,Beneke S,Bürkle A,Bereiter-Hahn J,Jendrach M

更新日期：2010-01-01 00:00:00

abstract：:Neurons that degenerate in the brains of persons with Alzheimer's disease accumulate mitochondrial amyloid precursor protein (APP), which is thought to negatively affect mitochondrial function and cellular homeostasis. Because proteins that enter mitochondria require assistance from chaperone proteins, we hypothesized...

journal_title：Mechanisms of ageing and development

authors： Yang TT,Hsu CT,Kuo YM

更新日期：2009-09-01 00:00:00

abstract：:The steroid hormone ecdysone influences Drosophila lifespan. Longevity is extended in mutants deficient for ecdysone synthesis or mutants of the ecdysone receptor (EcR). However, the underlying mechanisms remain unclear. Here we conditionally inactivated EcR by RNA interference or expression of dominant negative forms...

journal_title：Mechanisms of ageing and development

authors： Tricoire H,Battisti V,Trannoy S,Lasbleiz C,Pret AM,Monnier V

更新日期：2009-08-01 00:00:00

abstract：:The bone marrow of old adult mice ( approximately 2 years old) has reduced B lymphopoiesis; however, whether the B1 pathway in adult bone marrow is also compromised in senescence is not known. Herein, we show that phenotypic (IgM(-)Lin(-)CD93(+)[AA4.1(+)] CD19(+)B220(low/-)) B1 progenitors are retained in old bone mar...

journal_title：Mechanisms of ageing and development

authors： Alter-Wolf S,Blomberg BB,Riley RL

更新日期：2009-06-01 00:00:00

abstract：:In this paper we examined the impact of age on cognitive functions and the age-related modifications of egr1 expression, an inducible transcription factor with a confirmed role in synaptic plasticity and regulation of the proteasome activity, on pet dogs. Additionally, we examined the age-related changes of some eleme...

journal_title：Mechanisms of ageing and development

authors： Ghi P,Di Brisco F,Dallorto D,Osella MC,Orsetti M

更新日期：2009-05-01 00:00:00

abstract：:The tumor suppressors p16(INK4a) and p53 have been implicated as contributors to age-associated stem cell decline. Key functions of p53 are the induction of cell cycle arrest, senescence, or apoptosis in response to DNA damage. Here, we examine senescence, apoptosis, and DNA damage responses in a mouse accelerated agi...

journal_title：Mechanisms of ageing and development

authors： Hinkal GW,Gatza CE,Parikh N,Donehower LA

更新日期：2009-04-01 00:00:00

abstract：:The potential gain in life expectancy which could result from the complete elimination of mortality from cancer in the U.S. would not exceed 3 years if one were to consider cancer independently of other causes of death. In this paper, we review evidence of trade-offs between cancer and aging as well as between cancer ...

journal_title：Mechanisms of ageing and development

authors： Yashin AI,Ukraintseva SV,Akushevich IV,Arbeev KG,Kulminski A,Akushevich L

更新日期：2009-01-01 00:00:00

abstract：:The efficient use of nutrients is important in development and aging. In this study, we asked if the protein repair methyltransferase has a related or additional role in energy metabolism and stress response in the nematode Caenorhabditis elegans. Worms lacking the pcm-1 gene encoding this enzyme exhibit reduced longe...

journal_title：Mechanisms of ageing and development

authors： Gomez TA,Banfield KL,Clarke SG

更新日期：2008-12-01 00:00:00

abstract：:The polyphenol quercetin has recently been found to extend lifespan and increase stress resistance in the nematode Caenorhabditis elegans. The forkhead transcription factor DAF-16 has previously been linked to these effects. However, by using a daf-16(mgDf50) mutant strain, we show that quercetin exposure leads to inc...

journal_title：Mechanisms of ageing and development

authors： Saul N,Pietsch K,Menzel R,Steinberg CE

更新日期：2008-10-01 00:00:00

abstract：:Accumulation of oxidative DNA damage in the human brain has been implicated in etiologies of post-traumatic and age-associated declines in neuronal function. In neurons, because of high metabolic rates and prolonged life span, exposure to free radicals is intense and risk for accumulation of damaged DNA is amplified. ...

journal_title：Mechanisms of ageing and development

authors： Englander EW

更新日期：2008-07-01 00:00:00

abstract：:DNA synthesis is a remarkably vulnerable phase in the cell cycle. In addition to introduction of errors during semi-conservative replication, the inherently labile structure of the replication fork, as well as numerous pitfalls encountered in the course of fork progression, make the normally stable double stranded mol...

journal_title：Mechanisms of ageing and development

authors： Ruzankina Y,Asare A,Brown EJ

更新日期：2008-07-01 00:00:00

abstract：:DNA damage and mutations have been implicated as key causal events in the biological process of aging. In this context, it has been hypothesized that the complex of genome maintenance systems acts as a longevity assurance system by signaling and repairing damage or removing cells that are beyond repair. In the past, v...

journal_title：Mechanisms of ageing and development

authors： Vijg J

更新日期：2008-07-01 00:00:00

abstract：:Werner syndrome (WS) is an autosomal recessive progeroid syndrome caused by mutations in the Werner (Wrn) gene. WS patients have increased incidence of a number of chronic conditions including insulin resistance and type 2 diabetes. Since ingestion of foods that are high in fat and sugar is associated with increased i...

journal_title：Mechanisms of ageing and development

authors： Moore G,Knoblaugh S,Gollahon K,Rabinovitch P,Ladiges W

更新日期：2008-04-01 00:00:00

abstract：:Caloric restriction has been extensively investigated as an intervention that both extends lifespan and delays age-related disease in mammals. In mice, much interest has centered on evaluating gene expression changes induced by caloric restriction (CR) in particular tissue types, but the overall systemic effect of CR ...

journal_title：Mechanisms of ageing and development

authors： Swindell WR

更新日期：2008-03-01 00:00:00

abstract：:Loss of telomere length homeostasis has been linked to age-related disease especially cancer. In this review, we discuss two major causes of telomere dysfunction that potentially lead to tumorigenesis: replicative aging and environmental assaults. Aging has long been recognized as a source for telomere dysfunction thr...

journal_title：Mechanisms of ageing and development

authors： Gilley D,Herbert BS,Huda N,Tanaka H,Reed T

更新日期：2008-01-01 00:00:00

abstract：:Manganese superoxide dismutase (MnSOD or SOD2) is a key mitochondrial enzymatic antioxidant. Arguably the most striking phenotype associated with complete loss of SOD2 in flies and mice is shortened life span. To further explore the role of SOD2 in protecting animals from aging and age-associated pathology, we generat...

journal_title：Mechanisms of ageing and development

authors： Paul A,Belton A,Nag S,Martin I,Grotewiel MS,Duttaroy A

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND:It seems to be clear that hepatic age-related HMG-CoA reductase total activation is connected to a rise of reactive oxygen species (ROS). However, the mechanism by which ROS achieve this effect is unknown. Thus, in this work, we have performed a study of HMG-CoAR by analyzing the enzymes involved in its shor...

journal_title：Mechanisms of ageing and development

authors： Pallottini V,Martini C,Cavallini G,Bergamini E,Mustard KJ,Hardie DG,Trentalance A

更新日期：2007-11-01 00:00:00

abstract：:Chronic low-grade inflammation is involved in the pathogenesis of many disease conditions in humans and it is frequently quantified by measuring the blood concentration of C-reactive protein (CRP). Here we show that the CRP concentration in old people (nonagenarians) is, at least partially, genetically determined, and...

journal_title：Mechanisms of ageing and development

authors： Hurme M,Kivimäki M,Pertovaara M,Lehtimäki T,Karhunen PJ,Jylhä M,Hervonen A,Eklund C

更新日期：2007-10-01 00:00:00

abstract：:Caenorhabiditis elegans males live longer than hermaphrodites when cultured individually. Since hermaphrodites contain a pair of X chromosomes (XX) and males are XO (there is no Y chromosome in C. elegans), we questioned whether chromosomal differences per se might impact life span. The use of mutations in the sex-det...

journal_title：Mechanisms of ageing and development

authors： Hartman PS,Ishii N

更新日期：2007-07-01 00:00:00

abstract：:Werner syndrome (WS) is a premature aging and cancer-prone disease caused by loss of the RecQ helicase WRN protein. Cultured WS fibroblasts display high genomic instability and senesce prematurely. Epigenetic inactivation of the WRN gene occurs in numerous tumor types, in which WRN demonstrates tumor suppressor-like a...

journal_title：Mechanisms of ageing and development

authors： Opresko PL,Calvo JP,von Kobbe C

更新日期：2007-07-01 00:00:00

abstract：:There are reports demonstrating elevated levels of autoantibodies in elderly people. We now analyzed whether the strong inflammatory response associated with aging is interrelated with the production of autoantibodies, antinuclear antibodies (ANA). In a cohort of 284 nonagenarians the rate of ANA positivity was 12.3%,...

journal_title：Mechanisms of ageing and development

authors： Hurme M,Korkki S,Lehtimäki T,Karhunen PJ,Jylhä M,Hervonen A,Pertovaara M

更新日期：2007-05-01 00:00:00

abstract：:Relationships between nutrition and longevity are of growing interest. Here we analysed the influences of dietary restriction on the survival of Drosophila exposed to atmospheric oxygen or to chronic hypoxia. Dietary restriction was achieved by food dilution, by sucrose restriction or by yeast restriction. Sucrose and...

journal_title：Mechanisms of ageing and development

authors： Vigne P,Frelin C

更新日期：2007-05-01 00:00:00

abstract：:Older adults who are at risk of developing influenza illness, have a low level of influenza virus-stimulated cytotoxic T lymphocyte (CTL) activity as measured by an assay of granzyme B (GrB). The purpose of this study was to determine whether aging affected memory CTL populations identified by GrB expression in influe...

journal_title：Mechanisms of ageing and development

authors： Xie D,McElhaney JE

更新日期：2007-05-01 00:00:00

abstract：:In yeast, increasing the copy number of the nicotinamide adenine dinucleotide (NAD)-dependent deacetylase Sir2 extends lifespan, which can be inhibited by nicotinamide (Nam), the end-product of Sir2-mediated NAD-breakdown. Furthermore, the yeast pyrazinamidase/nicotinamidase PNC-1 can extend yeast lifespan by converti...

journal_title：Mechanisms of ageing and development

authors： van der Horst A,Schavemaker JM,Pellis-van Berkel W,Burgering BM

更新日期：2007-04-01 00:00:00

abstract：:The current increase in life expectancy observed in industrialized societies underscores the need to achieve a better understanding of the aging process that could help the development of effective strategies to achieve healthy aging. This will require not only identifying genes involved in the aging process, but also...

journal_title：Mechanisms of ageing and development

authors： Lai CQ,Parnell LD,Lyman RF,Ordovas JM,Mackay TF

更新日期：2007-03-01 00:00:00

abstract：:Researchers and clinicians interested in human diseases of DNA repair deficiency and premature aging gathered at the National Conference Center in Lansdowne, Virginia on 5-8 September 2006 to attend a workshop co-organized by Vilhelm Bohr (National Institute of Aging) and Kenneth Kraemer (National Cancer Institute). A...

journal_title：Mechanisms of ageing and development

authors： Kraemer KH,Sander M,Bohr VA

更新日期：2007-02-01 00:00:00

abstract：:Overproduction of oxidants and free radicals in ageing tissues induces nitro-oxidative stress, which has recently been implicated in the pathogenesis of cardiovascular dysfunction associated with ageing. Peroxynitrite, a strong cytotoxic oxidant damages proteins and DNA and activates several pathways causing tissue in...

journal_title：Mechanisms of ageing and development

authors： Radovits T,Seres L,Gero D,Lin LN,Beller CJ,Chen SH,Zotkina J,Berger I,Groves JT,Szabó C,Szabó G

更新日期：2007-02-01 00:00:00

abstract：:Several technologies that emerged in the post-genomic era have been particularly useful in dissecting the molecular mechanisms of complex biological processes through the systems approach. Here, we review how three of these technologies, namely transcriptional profiling, large-scale RNA interference (RNAi) and genome-...

journal_title：Mechanisms of ageing and development

authors： Lim CA,Ng HH

更新日期：2007-01-01 00:00:00

abstract：:Semantic distinctions between "normal" aging, "pathological" aging (or age-related disease) and "premature" aging (otherwise known as segmental progeria) potentially confound important insights into the nature of each of the complex processes. Here we review a recent, unexpected discovery: the presence of longevity-as...

journal_title：Mechanisms of ageing and development

authors： van de Ven M,Andressoo JO,Holcomb VB,Hasty P,Suh Y,van Steeg H,Garinis GA,Hoeijmakers JH,Mitchell JR

更新日期：2007-01-01 00:00:00

abstract：:Interfibrillar mitochondria (IFM) of the heart in aged Fischer 344 rats show a biochemical defect which might be reflected in their morphology. We examined by high resolution scanning electron microscopy over 5500 mitochondria to determine if a concomitant structural alteration existed. This methodology provides a mea...

journal_title：Mechanisms of ageing and development

authors： Riva A,Tandler B,Lesnefsky EJ,Conti G,Loffredo F,Vazquez E,Hoppel CL

更新日期：2006-12-01 00:00:00

abstract：:This study has characterised the time course of two major transcriptional adaptive responses to exercise (changes in antioxidant defence enzyme activity and heat shock protein (HSP) content) in muscles of adult and old male mice following isometric contractions and has examined the mechanisms involved in the age-relat...

journal_title：Mechanisms of ageing and development

authors： Vasilaki A,McArdle F,Iwanejko LM,McArdle A

更新日期：2006-11-01 00:00:00